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Is amlodipine a generic drug for epilepsy. In a double-blind, placebo-controlled crossover study, children and adults with refractory epilepsy were randomly assigned to receive amlodipine (0 mg/kg/day ) canadian pharmacy online ativan or placebo for 6 months. A significant increase of seizure frequency and number focal seizures was found in the amlodipine group. number of patients who experienced partial response following the intervention, as measured by a reduction in number of the main seizures, at end of the study (6 months) is shown in. Discussion This study was conducted to examine the efficacy and safety of amlodipine in the treatment refractory epilepsy. addition to the previous finding that drug has anticonvulsant properties, amlodipine possesses a direct inhibitory effect on glutamatergic transmission with a low affinity potential to GABA-A receptors and may be effective against different classes of antiepileptic drugs.1 Furthermore, the results of a previous study that investigated Tramadol hcl 50 mg for sale amlodipine's efficacy in nonresistant patients an open-label study showed a favorable response, with most (79%) of the patients becoming seizure-free without any drug-related adverse effects (AEs).2 The efficacy of this drug has been supported by other studies in animal models.3,4,5 The present study was conducted to determine its efficacy in refractory epilepsy of the pediatric variety. Amlodipine's anticonvulsant efficacy is supported by a previous study that assessed amlodipine's efficacy in a randomized, double-blind, placebo-controlled study. For the duration of study, overall number seizures remained the same in both experimental and control groups. However, the mean number of focal seizures, Temazepam kopen kruidvat defined as seizures more than one minute apart, decreased more in the amlodipine group, and was Online ultram buy statistically significant in the two groups.3 Clinical outcomes were also assessed. After the intervention, numbers of convulsive seizures and the seizure types were significantly greater than in the placebo group two groups.6 Furthermore, more than 90% of the patients did well, as assessed by seizure-free intervals and duration of epilepsy, clinical scores, suggesting that the patients were stabilized effectively. The safety of amlodipine in refractory epilepsy was evaluated by a study conducted in adults with refractory epilepsy.13 Amlodipine was evaluated in eight patients with refractory and epilepsy. Four patients in the amlodipine group and four patients in the placebo group were unable to remain on this drug. The total number of doses was 5 mg/kg/day and the frequency of adverse reactions was no different in the two groups. addition, incidence of adverse events that required treatment was greater in the amlodipine-treated group. Although safety evaluation in adults is less conclusive, the same results were observed in this study. The effects associated with amlodipine in refractory epilepsy were studied a double-blind, randomized, placebo-controlled study. Patients were randomized in a 2:1 ratio to receive placebo or amlodipine for 24 weeks. The number of convulsive and focal seizures was the same during course of study in both groups, but there was a significant reduction of the number main seizures in amlodipine group. The incidence of adverse events was less (20% compared with 32%) in the amlodipine-treated group. Amlodipine is a long-acting inhibitor of the GABA-A 1 receptor.6 A number of recent studies have demonstrated that amlodipine does not affect the efficacy of gabapentin.14,15 In present study, gabapentin was compared with amlodipine on seizure frequency and number of focal seizures. The convulsive seizures and number of seizure types were the same in two groups, but the mean number of focal seizures among gabapentin recipients (40%) and amlodipine (42%) decreased significantly in comparison with the decrease gabapentin group (4%). frequency of seizure-related adverse events (AEs) was significantly greater in gabapentin-treated participants.